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  • The Epidemic Deficiency of Progesterone

    The Epidemic Deficiency of Progesterone (an excerpt from The Life Extension Foundation).

    Throughout adult life, women will experience a gradual loss of critical hormones (besides
    estrogen), namely, progesterone. This decline becomes significant as women get closer to
    menopause. Symptoms of progesterone deficiency include premenstrual discomfort, night
    sweats, hot flashes, and a loss of well-being, including depressed feelings. During and after
    menopause, natural progesterone synthesis often ceases, causing menopausal miseries and
    degenerative diseases.
    Research by Dr. Ray Peat, the late Dr. John Lee, and others has shown that progesterone has
    many other beneficial uses, including improvement in bone density that prevents osteoporosis,
    and prevention of other menopausal symptoms.
    There are two types of bone-regulating cells: osteoclasts, which function to dissolve older bone,
    leaving tiny unfilled spaces behind, and osteoblasts, which move into these spaces and produce new
    bone. This process of dissolving older bone mass by osteoclasts and forming new bone by
    osteoblasts is the mechanism for the repair and continuing remodeling and strengthing of
    bone. Osteoblasts respond to progesterone and testosterone, while osteoclasts react to
    estrogen-like hormones, including the active phytoestrogens in soy. Without these hormones,
    osteoblasts and osteoclasts cease to function properly and deterioration of bone occurs.
    “The goal of progesterone supplementation is to restore normal physiologic levels of
    bioavailable progesterone.” (Lee et al. 1996)
    Besides making women feel better, progesterone may prevent the mental decline that can
    occur with aging. Progesterone increases neuronal energy production and protects brain cells.
    The late John Lee, one of the world’s foremost experts on progesterone therapy showed that
    20 times more progesterone is concentrated in brain cells than in blood serum (Lee et al. 1996).
    He postulated that progesterone may prevent mental decline in the elderly, and that recovery
    after brain trauma is promoted if progesterone levels are higher.
    Progesterone can be protective against, and a potential treatment for, breast cancer (Cowan et
    al. 1981). Cowan et al. showed the incidence of breast cancer was 5.4 times greater in women
    with low progesterone than in women who had favorable progesterone levels.
    To avoid confusion, use of the term progestin will refer mainly to the “unnatural” forms of
    progesterone, not progesterone itself. The side effects of Premarin® and Provera® may be the
    main reason that women stop taking their replacement hormones.
    An alternative to progestins is the option of using “natural” progesterone products. Natural
    progesterone is safer than synthetic drugs. A common form of natural progesterone is
    dispensed in a cream that is rubbed into appropriate areas of the body. This route of
    administration bypasses immediate metabolism by the liver and allows more hormone delivery
    to where it is needed most and less side effects in the liver.
    During transdermal replacement hormone therapy, the avoidance of the “first pass effect” (of
    metabolism by the liver) is ensured by the transdermal application of hormones and explains
    the superiority of this route of hormone administration (Foidart et al. 1998a). Transdermal
    progesterone cream has now been well-researched and shows an effect on the uterine lining
    (Anasti et al. 2001). It is excellent for the resolution of vasomotor symptoms of hot flashes
    (Leonetti et al. 1999).
    Natural progesterone should not be confused with the synthetic FDA-approved progestins that
    cause many side effects. Progestins do not provide the broad spectrum of benefits that have
    been shown for natural progesterone.
    At Axxess Medical Solutions we only use “bio-identical” “natural” hormone replacement and
    balancing therapies!
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